Flight schedule from O.R. Tambo International Airport
| Flight | Flight days | Departure | Arrival | Flight time | Airlines | Price | ||
|---|---|---|---|---|---|---|---|---|
| ET3858 | Johannesburg — Addis Ababa | tue | 05:19 | 10:53 | 4h 34m | Ethiopian Airlines | from $404 | search |
| KL592 | Johannesburg — Amsterdam | sun | 23:15 | 10:20 | 11h 5m | KLM | search | |
| KL592 | Johannesburg — Amsterdam | sun | 23:59 | 09:55 | 10h 56m | KLM | search | |
| KL592 | Johannesburg — Amsterdam | mon, tue, wed, thu, fri | 23:59 | 10:10 | 11h 11m | KLM | search | |
| KL592 | Johannesburg — Amsterdam | sat | 23:59 | 11:10 | 11h 11m | KLM | search | |
| ET21 | Johannesburg — Blantyre | wed, thu, fri, sat | 12:30 | 14:45 | 2h 15m | Ethiopian Airlines | search | |
| ET21 | Johannesburg — Blantyre | wed | 12:30 | 14:45 | 2h 15m | Malawi Airlines | search | |
| FA492 | Johannesburg — Bloemfontein | sat | 10:10 | 11:15 | 1h 5m | FlySafair | search | |
| FA846 | Johannesburg — Bloemfontein | fri, sun | 14:30 | 15:35 | 1h 5m | FlySafair | search | |
| 4Z114 | Johannesburg — Bulawayo | daily | 14:20 | 15:35 | 1h 15m | Airlink | search | |
| FA606 | Johannesburg — Cape Town | sat | 06:25 | 08:45 | 2h 20m | FlySafair | from $51 | search |
| FA692 | Johannesburg — Cape Town | daily | 08:00 | 10:15 | 2h 15m | FlySafair | from $51 | search |
| SA347 | Johannesburg — Cape Town | daily | 15:15 | 17:30 | 2h 15m | South African Airways | from $51 | search |
| W22025 | Johannesburg — Cape Town | tue | 19:00 | 21:10 | 2h 10m | Flexflight | from $51 | search |
| EK762 | Johannesburg — Dubai | daily | 13:25 | 23:40 | 8h 15m | Emirates | from $293 | search |
| EK766 | Johannesburg — Dubai | daily | 22:20 | 08:20 | 8h 0m | Emirates | from $293 | search |
| FA452 | Johannesburg — Durban | mon, thu | 10:10 | 11:20 | 1h 10m | FlySafair | from $44 | search |
| FA284 | Johannesburg — Durban | sun | 14:20 | 15:30 | 1h 10m | FlySafair | from $44 | search |
| FA221 | Johannesburg — Durban | fri | 16:54 | 17:43 | 48m | FlySafair | from $44 | search |
| FA246 | Johannesburg — East London | sun | 07:35 | 09:10 | 1h 35m | FlySafair | search | |
| DE2289 | Johannesburg — Frankfurt | mon, tue, wed, thu, fri, sun | 20:45 | 07:00 | 11h 15m | Condor (Green Island Livery) | search | |
| SA30 | Johannesburg — Gaborone | daily | 06:50 | 07:45 | 55m | South African Airways | search | |
| 4Z174 | Johannesburg — Gaborone | mon, tue, wed, thu, fri, sat | 08:45 | 09:40 | 55m | Airlink | search | |
| 4Z180 | Johannesburg — Gaborone | daily | 15:25 | 16:20 | 55m | Airlink | search | |
| SA38 | Johannesburg — Gaborone | daily | 16:25 | 17:20 | 55m | South African Airways | search | |
| BP208 | Johannesburg — Gaborone | daily | 19:30 | 20:40 | 1h 10m | Air Botswana | search | |
| FA254 | Johannesburg — George | sun | 07:00 | 09:00 | 2h 0m | FlySafair | from $85 | search |
| 4Z693 | Johannesburg — George | daily | 11:45 | 13:45 | 2h 0m | Airlink | from $85 | search |
| KP75 | Johannesburg — Libreville | thu | 05:30 | 09:55 | 5h 25m | ASKY Airlines | search | |
| KQ2775 | Johannesburg — Lusaka | fri | 01:50 | 03:50 | 2h 0m | Kenya Airways | search | |
| ZN306 | Johannesburg — Lusaka | tue, sat | 19:25 | 21:35 | 2h 10m | Zambia Airways | search | |
| ZN306 | Johannesburg — Lusaka | tue | 19:25 | 21:35 | 2h 10m | Naysa | search | |
| HM60 | Johannesburg — Mahe Island | fri, sun | 13:50 | 20:45 | 4h 55m | Air Seychelles | from $273 | search |
| TK38 | Johannesburg — Maputo | tue, thu, sat | 11:50 | 13:05 | 1h 15m | Turkish Airlines | from $73 | search |
| LH579 | Johannesburg — Munich | tue, thu, sun | 10:10 | 19:45 | 10h 35m | Lufthansa | search | |
| ET3858 | Johannesburg — Nairobi | mon | 03:18 | 07:51 | 3h 33m | Ethiopian Airlines | from $258 | search |
| EK9753 | Johannesburg — Nairobi | thu | 18:30 | 23:25 | 3h 55m | Emirates | from $258 | search |
| TK6130 | Johannesburg — Nairobi | mon | 18:40 | 23:55 | 4h 15m | Turkish Airlines | from $258 | search |
| SQ7344 | Johannesburg — Nairobi | sun | 18:50 | 00:10 | 4h 20m | Singapore Airlines | from $258 | search |
| TK6130 | Johannesburg — Nairobi | sat | 19:05 | 00:25 | 4h 20m | Turkish Airlines | from $258 | search |
| EK9747 | Johannesburg — Nairobi | fri, sat | 19:10 | 00:10 | 4h 0m | Emirates | from $258 | search |
| TK6130 | Johannesburg — Nairobi | mon | 19:15 | 01:30 | 5h 15m | Turkish Airlines | from $258 | search |
| 4Z72 | Johannesburg — Nairobi | mon | 20:30 | 01:30 | 4h 0m | Airlink | from $258 | search |
| 4Z230 | Johannesburg — Nampula | tue, thu, sat | 10:30 | 13:00 | 2h 30m | Airlink | search | |
| 4Z150 | Johannesburg — Ndola | daily | 10:15 | 12:35 | 2h 20m | Airlink | search | |
| 4Z246 | Johannesburg — Nossi-be | sun | 09:40 | 14:10 | 3h 30m | Airlink | search | |
| 4Z815 | Johannesburg — Polokwane | mon, tue, wed, thu, fri, sun | 16:20 | 17:15 | 55m | Airlink | search | |
| FA360 | Johannesburg — Port Elizabeth | mon, tue, wed, thu, fri | 11:10 | 13:00 | 1h 50m | FlySafair | from $51 | search |
| FA375 | Johannesburg — Port Elizabeth | sun | 12:50 | 14:35 | 1h 45m | FlySafair | from $51 | search |
| FA373 | Johannesburg — Port Elizabeth | mon, tue, wed, thu, sat | 13:05 | 14:50 | 1h 45m | FlySafair | from $51 | search |