Flight schedule from Tocumen International Airport
| Flight | Flight days | Departure | Arrival | Flight time | Airlines | Price | ||
|---|---|---|---|---|---|---|---|---|
| QR8158 | Panama City — Amsterdam | wed | 15:50 | 03:20 | 5h 30m | Qatar Airways | search | |
| QR8158 | Panama City — Amsterdam | tue, wed | 15:50 | 08:00 | 10h 10m | Qatar Airways | search | |
| KL758 | Panama City — Amsterdam | daily | 18:50 | 12:10 | 10h 20m | KLM | search | |
| CM309 | Panama City — Barranquilla | thu | 15:55 | 17:22 | 1h 27m | Copa Airlines | search | |
| AV41 | Panama City — Bogota | daily | 04:25 | 06:00 | 1h 35m | avianca | from $139 | search |
| 5Y79 | Panama City — Bogota | sun | 06:31 | 07:34 | 1h 2m | Atlas Air | from $139 | search |
| CM430 | Panama City — Bogota | wed, thu, fri, sat | 22:27 | 00:06 | 1h 39m | Copa Airlines | from $139 | search |
| CM430 | Panama City — Bogota | mon, tue, sun | 22:32 | 00:06 | 1h 34m | Copa Airlines | from $139 | search |
| CM260 | Panama City — Bridgetown | wed, thu, fri, sat | 09:06 | 13:22 | 3h 16m | Copa Airlines | from $437 | search |
| CM260 | Panama City — Bridgetown | mon | 09:06 | 13:21 | 3h 15m | Copa Airlines | from $437 | search |
| CM167 | Panama City — Buenos Aires | daily | 15:40 | 01:02 | 7h 22m | Copa Airlines | from $341 | search |
| CM346 | Panama City — Buenos Aires | daily | 19:24 | 04:30 | 7h 6m | Copa Airlines | from $341 | search |
| CM307 | Panama City — Cali | mon, tue, wed, thu, sat | 12:29 | 14:09 | 1h 40m | Copa Airlines | search | |
| CM307 | Panama City — Cali | fri, sun | 12:32 | 14:12 | 1h 40m | Copa Airlines | search | |
| CM316 | Panama City — Cancun | daily | 07:55 | 10:44 | 2h 49m | Copa Airlines | from $2,358 | search |
| CM324 | Panama City — Cancun | daily | 12:44 | 15:34 | 2h 50m | Copa Airlines | from $2,358 | search |
| CM224 | Panama City — Caracas | daily | 09:03 | 12:22 | 2h 19m | Copa Airlines | search | |
| CM254 | Panama City — Cartagena | mon, wed, thu, fri, sun | 06:55 | 08:06 | 1h 11m | Copa Airlines | from $233 | search |
| CM452 | Panama City — Cartagena | tue, wed, fri, sat | 09:47 | 11:00 | 1h 13m | Copa Airlines | from $233 | search |
| CM720 | Panama City — Comayagua | daily | 11:48 | 12:50 | 2h 2m | Copa Airlines | search | |
| CM28 | Panama City — David | daily | 18:13 | 19:38 | 1h 25m | Copa Airlines | search | |
| CM390 | Panama City — Guatemala City | daily | 18:36 | 20:01 | 2h 25m | Copa Airlines | from $250 | search |
| W81505 | Panama City — Guayaquil | mon | 02:00 | 04:05 | 2h 5m | Cargojet Airways | from $293 | search |
| W81505 | Panama City — Guayaquil | tue, wed, thu, fri | 04:15 | 06:20 | 2h 5m | Cargojet Airways | from $293 | search |
| CM418 | Panama City — Kingston | mon, tue, wed, thu, fri | 11:57 | 13:51 | 1h 54m | Copa Airlines | from $724 | search |
| CM337 | Panama City — Lima | daily | 21:18 | 00:55 | 3h 37m | Copa Airlines | search | |
| CM472 | Panama City — Los Angeles | daily | 11:57 | 17:03 | 7h 6m | Copa Airlines | search | |
| CM835 | Panama City — Medellin | fri, sun | 07:31 | 08:49 | 1h 18m | Copa Airlines | from $252 | search |
| CM835 | Panama City — Medellin | tue | 08:56 | 10:20 | 1h 24m | Copa Airlines | from $252 | search |
| QT4071 | Panama City — Medellin | sat | 22:05 | 23:17 | 1h 12m | avianca Cargo | from $252 | search |
| CM420 | Panama City — Mendoza | daily | 15:33 | 00:09 | 6h 36m | Copa Airlines | search | |
| CM120 | Panama City — Mexico City | daily | 09:21 | 12:10 | 3h 49m | Copa Airlines | from $382 | search |
| CM120 | Panama City — Mexico City | daily | 09:22 | 12:10 | 3h 48m | Copa Airlines | from $382 | search |
| CM136 | Panama City — Mexico City | daily | 11:41 | 14:30 | 3h 49m | Copa Airlines | from $382 | search |
| CM138 | Panama City — Mexico City | daily | 16:23 | 19:20 | 3h 57m | Copa Airlines | from $382 | search |
| CM226 | Panama City — Miami | daily | 08:01 | 12:07 | 3h 6m | Copa Airlines | search | |
| AA2964 | Panama City — Miami | tue, wed, thu, sun | 13:40 | 17:55 | 3h 15m | American Eagle | search | |
| AA2964 | Panama City — Miami | mon, fri | 13:40 | 18:02 | 3h 22m | American Eagle | search | |
| AA332 | Panama City — Miami | mon, sun | 15:51 | 20:10 | 3h 19m | American Eagle | search | |
| CM427 | Panama City — Miami | daily | 18:15 | 22:23 | 3h 8m | Copa Airlines | search | |
| CM432 | Panama City — Miami | daily | 21:33 | 01:40 | 3h 7m | Copa Airlines | search | |
| CM146 | Panama City — Montego Bay | daily | 09:14 | 11:15 | 2h 1m | Copa Airlines | search | |
| CM175 | Panama City — Monterrey | mon, tue, sat, sun | 19:40 | 23:14 | 4h 34m | Copa Airlines | search | |
| CM368 | Panama City — Montevideo | daily | 22:10 | 07:26 | 7h 16m | Copa Airlines | search | |
| CM821 | Panama City — Porto Alegre | daily | 15:16 | 00:25 | 7h 9m | Copa Airlines | search | |
| CM728 | Panama City — Punta Cana | tue, wed, fri, sat, sun | 22:32 | 02:05 | 2h 33m | Copa Airlines | from $432 | search |
| M76713 | Panama City — Quito | sat | 20:58 | 22:30 | 1h 32m | mas | search | |
| CM899 | Panama City — Rosario | daily | 18:55 | 03:53 | 6h 58m | Copa Airlines | search | |
| CM391 | Panama City — San Jose | mon, tue, sun | 18:34 | 19:01 | 1h 27m | Copa Airlines | from $296 | search |
| CM450 | Panama City — San Juan | daily | 18:40 | 22:29 | 2h 49m | Copa Airlines | search | |