Flight schedule from Roanoke-Blacksburg Regional Airport
| Flight | Flight days | Departure | Arrival | Flight time | Airlines | Price | ||
|---|---|---|---|---|---|---|---|---|
| DL2818 | Roanoke — Atlanta | daily | 06:00 | 07:36 | 1h 36m | Delta Connection | search | |
| DL4966 | Roanoke — Atlanta | sat | 14:55 | 16:37 | 1h 42m | Delta Connection | search | |
| DL3942 | Roanoke — Atlanta | mon | 15:13 | 16:48 | 1h 35m | Delta Connection | search | |
| DL5247 | Roanoke — Atlanta | mon, sat | 19:51 | 21:33 | 1h 42m | Delta Connection | search | |
| DL5247 | Roanoke — Atlanta | mon | 19:59 | 21:46 | 1h 47m | Delta Connection | search | |
| B68784 | Roanoke — Boston | wed | 00:30 | 01:58 | 1h 28m | JetBlue | search | |
| 2Q1260 | Roanoke — Charleston | sat | 07:45 | 08:45 | 1h 0m | Air Cargo Carriers | search | |
| AA5855 | Roanoke — Charlotte | daily | 06:00 | 07:33 | 1h 33m | American Eagle | search | |
| AA6008 | Roanoke — Charlotte | tue | 07:05 | 08:38 | 1h 33m | American Eagle | search | |
| AA5823 | Roanoke — Charlotte | sun | 11:02 | 12:25 | 1h 23m | American Eagle | search | |
| AA6042 | Roanoke — Charlotte | tue, wed | 14:50 | 16:15 | 1h 25m | American Eagle | search | |
| AA6042 | Roanoke — Charlotte | sat | 14:51 | 16:16 | 1h 25m | American Eagle | search | |
| AA6042 | Roanoke — Charlotte | mon, thu | 14:52 | 16:17 | 1h 25m | American Eagle | search | |
| AA5870 | Roanoke — Charlotte | tue | 19:23 | 20:49 | 1h 26m | American Eagle | search | |
| AA5870 | Roanoke — Charlotte | wed | 19:59 | 21:26 | 1h 27m | American Eagle | search | |
| AA5870 | Roanoke — Charlotte | mon, sat | 20:00 | 21:26 | 1h 26m | American Eagle | search | |
| AA4723 | Roanoke — Chicago | mon | 07:50 | 09:08 | 2h 18m | American Eagle | search | |
| AA4723 | Roanoke — Chicago | sun | 07:52 | 09:10 | 2h 18m | American Eagle | search | |
| UA5530 | Roanoke — Chicago | mon | 10:43 | 12:00 | 2h 17m | SkyWest Airlines | search | |
| UA4425 | Roanoke — Chicago | mon, tue, wed, sun | 17:35 | 18:52 | 2h 17m | United Express | search | |
| FX1362 | Roanoke — Fort Wayne | mon | 21:51 | 23:08 | 1h 17m | FedEx | search | |
| FX1362 | Roanoke — Fort Wayne | mon | 21:58 | 23:02 | 1h 4m | FedEx | search | |
| SY8137 | Roanoke — Gulfport | sun | 20:40 | 21:45 | 2h 5m | Sun Country Airlines | search | |
| FX1362 | Roanoke — Knoxville | fri | 21:45 | 22:43 | 58m | FedEx | search | |
| FX1362 | Roanoke — Knoxville | fri | 21:58 | 22:43 | 45m | FedEx | search | |
| G73384 | Roanoke — Little Rock | mon | 20:00 | 21:23 | 2h 23m | GoJet | search | |
| 5X1269 | Roanoke — Louisville | mon, tue, wed, thu, fri | 21:42 | 22:49 | 1h 7m | UPS | search | |
| 5X1269 | Roanoke — Louisville | tue | 21:42 | 22:55 | 1h 13m | UPS | search | |
| 5X1269 | Roanoke — Louisville | wed | 21:42 | 22:32 | 50m | UPS | search | |
| 5X1275 | Roanoke — Louisville | mon | 22:37 | 23:44 | 1h 7m | UPS | search | |
| FX1362 | Roanoke — Memphis | wed | 21:47 | 23:07 | 2h 20m | FedEx | search | |
| FX1362 | Roanoke — Memphis | thu | 21:51 | 22:52 | 2h 1m | FedEx | search | |
| FX1362 | Roanoke — Memphis | thu | 21:53 | 22:52 | 1h 59m | FedEx | search | |
| FX1362 | Roanoke — Memphis | wed | 21:56 | 22:39 | 1h 43m | FedEx | search | |
| FX1362 | Roanoke — Memphis | tue, wed, thu | 21:58 | 22:52 | 1h 54m | FedEx | search | |
| FX1362 | Roanoke — Memphis | tue | 22:35 | 23:07 | 1h 32m | FedEx | search | |
| B69005 | Roanoke — Milwaukee | mon | 14:30 | 15:04 | 1h 34m | JetBlue | search | |
| DL5321 | Roanoke — New York | daily | 07:05 | 08:47 | 1h 42m | Delta Connection | search | |
| AA4688 | Roanoke — New York | wed | 16:40 | 18:18 | 1h 38m | American Eagle | search | |
| AA4688 | Roanoke — New York | sun | 17:08 | 18:48 | 1h 40m | American Eagle | search | |
| G43001 | Roanoke — Orlando | fri | 15:19 | 17:08 | 1h 49m | Allegiant Air | search | |
| G43003 | Roanoke — Orlando | mon | 16:02 | 17:51 | 1h 49m | Allegiant Air | search | |
| AA5931 | Roanoke — Philadelphia | mon, tue, wed, thu, fri, sat | 08:15 | 09:45 | 1h 30m | American Eagle | search | |
| AA6131 | Roanoke — Philadelphia | tue, wed, thu, fri, sun | 18:04 | 19:36 | 1h 32m | American Eagle | search | |
| AA6131 | Roanoke — Philadelphia | sat | 18:48 | 20:20 | 1h 32m | American Eagle | search | |
| SY8218 | Roanoke — Richlands | fri | 13:45 | 14:45 | 1h 0m | Sun Country Airlines | search | |
| SY8625 | Roanoke — San Jose | tue | 15:00 | 17:30 | 5h 30m | Sun Country Airlines | search | |
| G42999 | Roanoke — Sarasota | fri | 15:06 | 17:12 | 2h 6m | Allegiant Air | search | |
| G42988 | Roanoke — Sarasota | fri | 17:50 | 19:54 | 2h 4m | Allegiant Air | search | |
| G41020 | Roanoke — Tampa | thu, sun | 14:58 | 16:54 | 1h 56m | Allegiant Air | search | |