Cheap flights Medellin — Santiago (MDE — SCL)

Good to know - Cheap tickets Medellin — Santiago

Cheapest flight found $171
Minimal flight time 5h 50m
Flight distance 4442 km
Most popular airline avianca

Airfare Medellin – Santiago by month

Here you can find out in what months how much a ticket Medellin – Santiago costs to buy cheap plane tickets.

Month One-way Round-trip
January 2026
November 2025
October 2025
September 2025
August 2025
May 2025
April 2025
March 2025
February 2025
January 2025
December 2024
November 2024

Remember that the optimal time for booking air tickets is 59 days before the departure date, this is the average time at which air tickets were sold at the lowest prices.

Schedule of direct flights Medellin — Santiago

Departure Arrival Flight days Flight Airlines Flight time Airports
17:50 01:40 wed, fri AV147 avianca 5h 50m Jose Maria Cordova International Airport — Arturo Merino Benitez Airport Select dates
21:04 04:12 wed, thu JA1361 JetSMART 6h 8m Jose Maria Cordova International Airport — Arturo Merino Benitez Airport Select dates
All routes

Popular airlines flying Medellin — Santiago

Flight Medellin – Santiago is served by 9 airlines.  2 airlines operate direct flights.


Airlines with direct flights


Other airlines flying with transfers

Sales of tickets from Medellin to Santiago in the last 48 hours

2025-09-01 one-way

2025-09-01 one-way

Flights Medellin — Santiago

The selection of cheap flights Medellin — Santiago

Here you can find and purchase the cheapest flights Medellin — Santiago from $171 and Medellin — Santiago — Medellin from $150.

The price of the flight Medellin — Santiago (Chile) — Medellin from $150 (round-trip).

The average price of the flight Medellin — Santiago (Chile) — Medellin $555 (round-trip).

Low cost flights Medellin — Santiago (MDE — SCL)

The distance between Medellin and Santiago 2760 miles (or 4442 kilometres).

The time difference between Medellin and Santiago is 2 h.

Minimal flight time from Medellin to Santiago 5h 50m.

LowCostClub always do a comparison of airfares Medellin — Santiago with several airlines (include avianca, JetSMART). They will always give you all available options so you can find the cheapest flight to Santiago. In addition, you can choose the platform where you want to place your orders. There are also special offers for air tickets Medellin — Santiago. Last week, for instance, the cheapest round-trip prices stood at $150 while the cheapest one-way price that was available within the last week cost $171

Routes from nearby cities to Santiago

A flight from a neighbouring city can help you save money on plane tickets.

Most often, departures to Santiago are from Bogota, this is the cheapest flight from $136. The nearest airports from Medellin with a flight to Santiago are located in Ibague.

Popular International routes from Medellin

Popular routes from Santiago

If you are going to fly from Santiago, then study the popular flights. The most popular flights from Santiago:

Popular domestic routes from Medellin

FAQ about Medellin — Santiago

Yes, you can fly from Medellin to Santiago. Medellin has 2 airports (Enrique Olaya Herrera Airport, Jose Maria Cordova International Airport) for flights. avianca, JetSMART depart from Medellin on wed, thu, fri. There are non-direct flights through American Eagle, Arajet, Atlas Air, avianca Cargo, Copa Airlines, FedEx, LATAM Airlines, LATAM Cargo, LATAM Cargo Colombia.

A direct flight lasts an average of 5h 50m, during which time the aircraft covers a distance of 4442 km.

The price of flights Medellin — Santiago starts from $171.

Planes fly Medellin — Santiago 3 times a week on the following days: wed, thu, fri

In Medellin — Enrique Olaya Herrera Airport, Jose Maria Cordova International Airport. In Santiago — Arturo Merino Benitez Airport, Los Cerrillos.

The following flights fly between Medellin and Santiago: AV147, JA1361

High season is considered to be and the cheapest month is . Enter your preferred airports (or cities) and dates into the search form above to unlock the latest Medellin — Santiago flight deals.

The following airlines have direct flights Medellin — Santiago: avianca, JetSMART.

All the following airlines flights Medellin — Santiago: American Eagle, Arajet, Atlas Air, avianca, avianca Cargo, Copa Airlines, FedEx, JetSMART, LATAM Airlines, LATAM Cargo, LATAM Cargo Colombia.

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